ASCO Audio Journal of Oncology – August 1st 2006

John Neoptolemos

Wilko Weichert

Christophe Nemos

Pancreatic Cancer: Adjuvant Chemotherapy Improves Outlook for Patients with Resectable Tumors – ESPAC Trial Results

REFERENCE: National Cancer Research Institute Upper Gastrointestinal Cancer Group Studies Conference, Royal College of Physicians, London July 6th, 2006John Neoptolemos, Royal Liverpool University HospitalEncouraging progress regarding adjuvant chemotherapy for patients with resectable pancreatic cancer was reported at the National Cancer Research Institute Upper Gastrointestinal Cancer Conference in London. Peter Goodwin spoke withJohn Neoptolemosof Liverpool University about improvements in survival reported by the ESPAC trial of adjuvant chemotherapy, growth-factor directed therapies, gemcitabine, and capecitabine (reported at the conference byNaureen Starlingof the Royal Marsden Hospital in Surrey), and news about a new pancreatic cancer vaccine (announced byGaryMiddletonfrom the Royal Surrey Hospital in Guildford).

NFkB Transcription Factor: A Key To Controlling Pancreatic Cancer Progression?

REFERENCE: American Association for Cancer Research 97th Annual Meeting 1st-5th April 2006, Washington, DC. Abstract 414Wilko Weichert, Charité University Hospital, BerlinExciting new insights into the mechanism of pancreatic cancer progression were unveiled at the American Association for Cancer Research Annual Meeting in Washington, DC.Wilko Weichertfrom the Charité University Hospital in Berlin presented his group’s study looking at the behavior of the gene transcription factor NFkB, which modulates programmed cell death (apoptosis) and consequently the proliferative behavior of the tumor. He told Peter Goodwin how their recent investigation has given hope that this mechanism may be harnessed for therapy that will complement existing drug treatments for patients with pancreatic cancer.

MUC4 mRNA in Human Blood: Prognosis and Diagnosis of Pancreatic Adenocarcinoma

REFERENCE: American Association for Cancer Research 97th Annual Meeting 1st-5th April 2006, Washington, DC. Abstract 415Christophe Nemos, University of Nebraska Medical Center, OmahaA new blood test for pancreatic cancer was under discussion at the American Association for Cancer Research Annual Meeting held in Washington, DC. In some patients the results of the test proved to signal pancreatic cancer six months before the disease became detectable by other means.Christophe Némosof the University of Nebraska in Omaha told Peter Goodwin about his group’s use of MUC4 mRNA molecule normally present in tumor tissue, which has now been measured in the blood. The hope is that very early detection of the disease could improve further the rates of survival made possible by early resection combined with chemotherapy.